Colistin and polymyxin B: A re-emergence
نویسندگان
چکیده
منابع مشابه
Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus.
In the face of diminishing therapeutic options for the treatment of infections caused by multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and polymyxin B. These antibiotics became available clinically in the 1950s, when understanding of antimicrobial pharmacology and regulatory requirements for approval of drugs was substantially less than today. At the 1s...
متن کاملColistin and polymyxin B: peas in a pod, or chalk and cheese?
Colistin and polymyxin B have indistinguishable microbiological activity in vitro, but they differ in the form administered parenterally to patients. Polymyxin B is administered directly as the active antibiotic, whereas colistin is administered as the inactive prodrug, colistin methanesulfonate (CMS). CMS must be converted to colistin in vivo, but this occurs slowly and incompletely. Here we s...
متن کاملComparison of nephrotoxicity of Colistin with Polymyxin B administered in currently recommended doses: a prospective study
BACKGROUND The most important concern with polymyxins (Colistin and Polymyxin B) use is nephrotoxicity. There is no prospective data comparing nephrotoxicity of these two drugs, when administered in high doses and as per current recommendations. We conducted a prospective study to compare their trend of nephrotoxicity in our patient population. METHODS Our study included adult ICU patients wh...
متن کاملRespiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs
Polymyxins B and E (colistin) exert a bactericidal effect on the gram-negative bacterial cell wall, causing permeability changes in the cytoplasmic membrane, leading to cell death. Their use was substantially decreased in clinical practice from the 1970s to 2000s due to their significant nephrotoxicity and neurotoxicity compared to the newly introduced antibiotics. The increasing prevalence of ...
متن کاملEffectiveness of acetic acid, betadine, amphyll, polymyxin B, colistin, and gentamicin against Pseudomonas aeruginosa.
The in vitro effectiveness of three germicides and three chemotherapeutic drugs against hospital-isolated strains of Pseudomonas aeruginosa was determined. Solutions of 1% acetic acid, 0.5% Amphyll, and 0.1% Betadine were bactericidal for six strains tested within 15 min at room temperature. Over a 3-year period at the Albany Medical Center Hospital, the percentages of strains of P. aeruginosa ...
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ژورنال
عنوان ژورنال: Indian Journal of Critical Care Medicine
سال: 2009
ISSN: 0972-5229,1998-359X
DOI: 10.4103/0972-5229.56048